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Reticulocytes: biological variations and reference limits

P Tarallo1, J C Humbert, P Mahassen

  • 1Centre de Médecine Préventive, Vandoeuvre-lès-Nancy, France.

European Journal of Haematology
|July 1, 1994
PubMed
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Automated reticulocyte counts using flow cytometry reveal significant sex-based differences in adults. Reference ranges are provided for erythropoietic activity assessment in healthy individuals.

Area of Science:

  • Hematology
  • Clinical Laboratory Science

Background:

  • Reticulocyte count is a key indicator of red blood cell production (erythropoiesis).
  • Automated methods, particularly flow cytometry, enhance the accuracy and reproducibility of reticulocyte counting.

Purpose of the Study:

  • To establish reference limits for reticulocyte counts in a large cohort of healthy individuals.
  • To investigate the influence of age, sex, and other factors on reticulocyte counts.

Main Methods:

  • Flow cytometry (Sysmex R-3000) with Auramine-O fluorochrome was used for reticulocyte enumeration.
  • 1219 healthy subjects aged 4 to over 60 years were analyzed.
  • Data were stratified by age group and sex.

Main Results:

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  • No significant sex-based difference in reticulocyte counts was observed in individuals aged 4-19 years.
  • Adult men (over 20 years) showed significantly higher reticulocyte counts than adult women.
  • Menstrual cycle, oral contraceptives, menopause, and moderate smoking did not significantly affect reticulocyte counts.

    • Conclusions:

    • Sex is a significant factor influencing reticulocyte counts in adults, with men exhibiting higher values.
    • The study provides age- and sex-specific reference ranges for reticulocyte counts.
    • Automated flow cytometry offers a reliable method for assessing erythropoietic activity.