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Folic acid absorption in pregnancy
British Journal of Obstetrics and Gynaecology
|January 1, 1975
Summary
Folic acid absorption remains unchanged during early to mid-pregnancy. Studies show pregnant and non-pregnant women absorb folic acid similarly, indicating no significant differences in retention during the first 26 weeks.
Area of Science:
- Nutritional Science
- Maternal-Fetal Medicine
- Gastroenterology
Background:
- Folic acid is crucial for fetal development and maternal health.
- Understanding folate absorption during pregnancy is vital for nutritional guidelines.
Purpose of the Study:
- To investigate whether folic acid absorption differs between pregnant and non-pregnant women.
- To assess folate retention in early to mid-pregnancy.
Main Methods:
- Radioactive tracer study using tritiated folic acid (10 muCi) with a 2 mg dose.
- Absorption and retention of folic acid were measured in six non-pregnant women and nine pregnant women (10-26 weeks gestation).
Main Results:
- Folic acid absorption ranged from 65% to 95%, with a mean of 80% in both groups.
- No significant difference in folic acid absorption or retention was observed between pregnant and non-pregnant subjects.
- Absorption levels indicate efficient folate uptake throughout the studied period.
Conclusions:
- Pregnancy does not alter folic acid absorption in the first 26-28 weeks.
- Maternal folate status is likely maintained through normal dietary intake and absorption during early to mid-pregnancy.
- Further research may explore later stages of gestation.