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A "primitive" catastrophic antiphospholipid syndrome

P Vivaldi1, C Andreotti, C Mazzon

  • 1Second Medical Division, St. Chiara General Hospital, Trento, Italy.

Haematologica
|March 1, 1994
PubMed

A female patient affected by a thrombotic syndrome due to non SLE-related antiphospholipid antibodies (APA), developed a serious, non inflammatory, thrombotic macroangiopathy and uremic-hemolytic syndrome during oral anticoagulant therapy. She was treated with aspirin, dipyridamole i.v. and with a total of 14 fresh frozen plasma exchange (PEX), but the thrombotic syndrome only showed a partial response with the APA titre dropping considerably. Renal failure did not improve because of acute cortical necrosis. The patient died from infective complications.

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