Related Experiment Videos
Vitreous amyloidosis without systemic or familial involvement
F Salvador1, C Mateo, J Alegre
1Department of Ophthalmology, University Hospital Vall D'Hebron, Barcelona, Spain.
International Ophthalmology
|January 1, 1993
Summary
Vitreous amyloidosis, a rare symptom of Transthyretin hereditary Amyloidosis, can occur without systemic involvement or family history. This case highlights vitreous opacities as a potential isolated sign of this rare amyloidosis form.
Area of Science:
- Ophthalmology
- Neurology
- Genetics
Background:
- Vitreous amyloidosis is a rare manifestation of Transthyretin hereditary Amyloidosis (ATTR).
- It is most commonly associated with Familial Amyloidotic Polyneuropathy type I.
- Vitreous opacities can be an early or sole presenting symptom.
Observation:
- A case of vitreous amyloidosis in an 80-year-old man is presented.
- The patient exhibited no evidence of systemic amyloid involvement.
- No family history of amyloidosis was reported.
Findings:
- This case demonstrates vitreous amyloidosis presenting in isolation.
- The absence of systemic disease and family history is noteworthy.
- Vitreous opacities were the primary clinical finding.
Implications:
- Suggests vitreous amyloidosis may occur independently of systemic ATTR.
- Highlights the importance of considering ocular examination in undiagnosed amyloidosis.
- Warrants further investigation into isolated vitreous amyloidosis etiology and prevalence.