SEP spectral analysis of cholesterol rich rats

In this study, twenty four albino rats, weighing between 180 and 200 g were tested. One half was fed with a diet containing 1% cholesterol for 12 weeks and the other half was fed with a normal lab diet for the same period. After the experimental period, the plasma cholesterol level in the diet group was 134.04 +/- 21.11 mg/dl compared with the control group 72.72 +/- 10.5 mg/dl. In the two groups, SEPs were recorded from central (Cz) referenced to frontal (Fz) following left posterior tibial nerve (PTN) stimulation. Amplitude spectra of SEPs were computed by Fast Fourier Transform (FFT) algorithm. Their amplitude maxima were found to occupy the frequency bands of 1-3.5, 4-5, 6-7, 8-10, 11-12, 13-20, 20.5-36 and 36 Hz and above. The decibel (dB) values of the maxima were statistically lower for hypercholesterolemia than for the normals in the all the frequency bands.