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Modulation by intracellular Ca++ of GABA activated Cl- extrusion from Deiters' neuron
M V Rapallino1, A Cupello, H Hydén
1Centro di Neurofisiologia Cerebrale, C. N. R., Genova, Italy.
The International Journal of Neuroscience
|June 1, 1993
Abstract:
The increase in 36Cl- in --> out permeation across plasma membranes from the Deiters' neurons by GABA on the cytoplasmic side is modulated by Ca++. The GABA stimulation was maximal with Ca++ on the intracellular side at the physiologically likely concentration of 3 x 10(-8) M. A lower effect was found in the 10(-7) - 10(-5) M [Ca++]i range with a total disappearance of it at [Ca++] of .2 mM. This Cl- extrusion mechanism is likely to be involved in the establishment of a Cl- out --> in electrochemical gradient. Modulation of it by intracellular Ca++ transients may be of physiological importance.