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Thyroid hormone changes in a cold air environment after local cold acclimation

G Savourey1, J P Caravel, B Barnavol

  • 1Unité de Thermophysiologie, Centre de Recherches du Service de Santé des Armées, La Tronche, France.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 1, 1994
PubMed
Summary

Cold exposure alters thyroid hormones (TH) in men. Local cold acclimation led to decreased triiodothyronine (TT3) and suggested hypothermic adaptation, potentially indicating a "T3 polar syndrome."

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Area of Science:

  • Environmental Physiology
  • Endocrinology

Background:

  • Thyroid hormones (TH) play a crucial role in thermoregulation.
  • Standard cold air tests (SCAT) are used to assess physiological responses to cold.

Purpose of the Study:

  • To investigate the impact of a standard cold air test (SCAT) on serum thyroid hormones (TH) in euthyroid men.
  • To evaluate the influence of local cold acclimation on these TH responses.

Main Methods:

  • Eight euthyroid men underwent a SCAT (1°C, 2 hours, nude, at rest) before and after local cold acclimation.
  • Serum levels of total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), and thyrotropin (TSH) were measured.
  • TH values were corrected for plasma volume reduction (delta PV).

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Main Results:

  • SCAT induced plasma volume reduction (-9 to -11%) irrespective of acclimation.
  • Before correction, TT4, TT3, and TSH increased during SCAT; FT4 and FT3 did not change.
  • After correction, FT4 and FT3 increased during SCAT.
  • Following cold acclimation, a significant decrease in TT3 was observed, suggesting hypothermic adaptation and a potential "T3 polar syndrome".

Conclusions:

  • Thyroid hormone responses to SCAT are influenced by plasma volume changes.
  • Local cold acclimation may lead to decreased TT3 levels, indicating adaptive changes in thyroid hormone metabolism.
  • These findings suggest a potential "T3 polar syndrome" associated with cold adaptation.