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Polymerase chain reaction for detection of herpes simplex virus encephalitis

J Aslanzadeh1, D J Skiest

  • 1University of Connecticut School of Medicine, Farmington 06030.

Journal of Clinical Pathology
|June 1, 1994
PubMed

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Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...