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Studies on interrelations between eosinophilia, serum IgE and tissue mast cells
Clinical Allergy
|June 1, 1975
Summary
Peripheral blood eosinophilia does not always correlate with elevated serum IgE. Atopic allergy is indicated by tissue eosinophilia, mast cell hyperplasia, and increased IgE, distinguishing Kimura
Area of Science:
- Immunology
- Dermatology
- Pathology
Background:
- Peripheral blood eosinophilia is observed in various diseases.
- Serum immunoglobulin E (IgE) levels are often evaluated in allergic conditions.
- Distinguishing between different eosinophilic disorders is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To investigate the relationship between peripheral blood eosinophilia and serum IgE levels across different diseases.
- To differentiate atopic allergy-related eosinophilic conditions from other eosinophilic disorders.
- To clarify the classification of eosinophilic granuloma of soft tissue (Kimura's disease).
Main Methods:
- Review of clinical data and laboratory findings from patients with peripheral blood eosinophilia.
- Analysis of serum IgE levels in conjunction with tissue eosinophilia and mast cell presence.
- Comparative pathological examination of Kimura's disease and histiocytosis X.
Main Results:
- Peripheral blood eosinophilia is not consistently associated with elevated serum IgE.
- Tissue eosinophilia, mast cell hyperplasia, and elevated IgE collectively suggest atopic allergy.
- Eosinophilic granuloma of soft tissue (Kimura's disease) exhibits characteristics distinct from histiocytosis X.
Conclusions:
- Serum IgE levels are not a universal marker for all conditions involving eosinophilia.
- Atopic allergy is characterized by specific patterns of tissue eosinophilia and IgE elevation.
- Kimura's disease represents a distinct clinicopathological entity separate from histiocytosis X.