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A population-based Danish data resource with possible high validity in pharmacoepidemiological research

H T Sørensen1, B O Larsen

  • 1Department of Internal Medicine V, Aarhus University Hospital, Denmark.

Journal of Medical Systems
|February 1, 1994
PubMed
Summary

Pharmacoepidemiology relies on ongoing monitoring due to incomplete drug effect knowledge. Denmark

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Area of Science:

  • Pharmacoepidemiology
  • Public Health
  • Drug Safety Monitoring

Background:

  • Incomplete understanding of drug effects necessitates continuous epidemiological surveillance.
  • The Danish National Health Service subsidizes prescription drugs, facilitating data collection.
  • Pharmacy accounting systems are increasingly computerized, with 96% adoption by 1992.

Purpose of the Study:

  • To highlight the need for new data sources in pharmacoepidemiology.
  • To assess the validity of Danish data sources for drug effect monitoring.
  • To explore the utility of existing Danish registries for adverse drug event detection.

Main Methods:

  • Cross-checking data from the Danish Hospital Register.
  • Utilizing birth and congenital malformation registries.

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  • Leveraging computerized pharmacy accounting systems (though limited for adverse events).

    • Main Results:

    • Computerized pharmacy systems do not directly provide adverse drug effect data.
    • Danish registries, including the Danish Hospital Register, offer valuable data for pharmacoepidemiology.
    • Despite methodological challenges, Danish population-based data sources exhibit high validity.

    Conclusions:

    • There is a significant need for novel data sources to enhance pharmacoepidemiological research.
    • Existing Danish population-based registries provide a valid resource for drug safety monitoring.
    • Cross-referencing multiple Danish registries can yield crucial information on adverse drug events.