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Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols
C E Heltzel1, A A Gunatilaka, D G Kingston
1Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212.
Journal of Natural Products
|May 1, 1994
Abstract:
The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicensis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.