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Esperamicin P, the tetrasulfide analog of esperamicin A1
J A Beutler1, P Clark, A B Alvarado
1PRI/DynCorp., NCI-Frederick Cancer Research & Development Center, MD 21702-1201.
Journal of Natural Products
|May 1, 1994
Abstract:
A minor congener of esperamicin A1 [1], designated esperamicin P (BMY-41339, 2), was isolated from a fermentation broth of Actinomadura verrucosospora and determined to differ from esperamicin A1 by having a methyl tetrasulfide moiety instead of a methyl trisulfide. It was active against xenografted tumors in mice and exhibited antimicrobial activity. Interconversions of 2 and 1 have been observed for DMSO solutions of both congeners at room temperature.