Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CT changes associated with normal aging of the human brain

J S Meyer1, S Takashima, Y Terayama

  • 1Department of Neurology, Baylor College of Medicine and Neurology, Houston.

Journal of the Neurological Sciences
|May 1, 1994
PubMed
Summary

Normal aging causes a decline in cortical gray matter density (polio-araiosis) after age 60, linked to reduced blood flow but not atrophy. This may reflect decreased synaptic density and metabolic demand.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why emergency XeCT-CBF should become routine in acute ischemic stroke before thrombolytic therapy.

The Keio journal of medicine·2000
Same author

XE-CT CBF changes during normative aging, cognitive decline and dementia.

The Keio journal of medicine·2000
Same author

Distinguishing patients with senile dementia of Alzheimer type and normal elderly subjects utilizing xenon CT-CBF and multivariate analysis.

The Keio journal of medicine·2000
Same author

Diagnosing aneurysmal and unicameral bone cysts with magnetic resonance imaging.

Clinical orthopaedics and related research·2000
Same author

Cocaine up-regulates norepinephrine transporter binding in the rat placenta.

European journal of pharmacology·1999
Same author

Risk factors accelerating cerebral degenerative changes, cognitive decline and dementia.

International journal of geriatric psychiatry·1999

Area of Science:

  • Neuroimaging
  • Gerontology
  • Neurology

Background:

  • Understanding normal brain aging is crucial for identifying pathological conditions like Alzheimer's and vascular dementias.
  • Cerebral tissue density and perfusion changes are key indicators of brain health over time.

Purpose of the Study:

  • To establish normative data for cerebral gray and white matter tissue densities in normal aging using computed tomography (CT).
  • To investigate the relationship between aging, tissue density changes, and cerebral blood flow (CBF).

Main Methods:

  • A cross-sectional study involving 81 neurologically and cognitively normal volunteers of varying ages.
  • Measurement of cerebral compartmental densities using plain CT scans.
  • Assessment of cerebral blood flow (CT-CBF) during stable xenon inhalation.

Related Experiment Videos

Main Results:

  • A progressive decline in cortical gray matter tissue density (polio-araiosis) was observed after age 60.
  • Cortical polio-araiosis correlated with regional hypoperfusion but not cortical atrophy.
  • Leuko-araiosis in normal aging showed a direct correlation with cortical atrophy.

Conclusions:

  • Age-related cortical hypodensity (polio-araiosis) may indicate reduced synaptic density and metabolic demand.
  • The findings suggest anterograde axonal degeneration plays a role in leuko-araiosis during normal aging.