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[Molecular cytogenetic approach on malignant lymphoma]
1Department of Clinical Laboratory and Medicine, Tohoku University School of Medicine, Sendai.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|July 1, 1994
Summary
Cytogenetic and molecular analyses, including chromosome and gene rearrangement detection, aid in distinguishing malignant lymphoma from benign conditions. These methods offer valuable criteria for accurate lymphoma diagnosis.
Area of Science:
- Oncology
- Genetics
- Pathology
Context:
- Distinguishing malignant lymphoma from benign lymphadenopathy presents diagnostic challenges.
- Cytogenetic and molecular analyses offer objective criteria for lymphoma diagnosis.
Purpose:
- To evaluate the utility of cytogenetic and molecular analyses in diagnosing malignant lymphoma.
- To differentiate lymphoma from reactive or benign lymphadenopathy.
Summary:
- Cytogenetic studies reveal chromosome translocations and deletions in lymphoma cells.
- Molecular analysis identifies immunoglobulin (Ig) gene or T cell receptor gene rearrangements.
- Polymerase chain reaction (PCR) can amplify translocation-specific fragments, such as in t(14;18) cases.
Impact:
- Chromosome and gene rearrangement analysis provides a reliable method for lymphoma diagnosis.
- These techniques improve the accuracy of clinical lymphoma diagnosis.