Related Experiment Videos
Methemoglobinemia from topically applied anesthetic spray
S F Dinneen1, D N Mohr, V F Fairbanks
1Division of Endocrinology/Metabolism, Mayo Clinic Rochester, Minnesota 55905.
Mayo Clinic Proceedings
|September 1, 1994
Summary
Topical anesthetic sprays, used before procedures like endoscopy, can rarely cause toxic methemoglobinemia. This serious side effect can occur even in healthy individuals, highlighting the need for prompt recognition and treatment.
Area of Science:
- Anesthesiology
- Pharmacology
- Toxicology
Background:
- Topical anesthetic sprays are frequently used for premedication in general anesthesia and endoscopic procedures.
- These agents are generally considered safe with a low incidence of adverse events.
Observation:
- Two cases of toxic methemoglobinemia are reported following the use of topical anesthetic spray before endoscopy.
- Standard doses were administered, yet significant methemoglobin levels (45% and 38%) developed rapidly.
Findings:
- Patients presented with toxic methemoglobinemia despite having normal erythrocyte methemoglobin reductase levels.
- This suggests that predisposing factors are not necessary for the development of this rare complication.
Implications:
- Toxic methemoglobinemia is a potentially fatal but treatable condition.
- Healthcare providers must be vigilant in recognizing this adverse effect associated with topical anesthetic spray use.
- Early diagnosis and management are crucial for patient safety during procedures involving topical anesthetics.