Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human meningioma antigens

W D Winters, J R Rich

    International Journal of Cancer
    |May 15, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified specific antibodies in the blood of brain tumor patients. These antibodies react with meningioma-associated antigens, aiding in the diagnosis of central nervous system tumors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Re-evaluating antibody-drug conjugate linker stability: assessment, interpretation, and clinical translation.

    Annals of oncology : official journal of the European Society for Medical Oncology·2026
    Same author

    First Report of Tomato spotted wilt virus in Habanero and Tabasco Peppers in Florida.

    Plant disease·2019
    Same author

    First Report of Meloidogyne partityla on Pecan in Florida.

    Plant disease·2019
    Same author

    Inhibition of Rotylenchulus reniformis Penetration of Tomato and Cotton Roots with Foliar Applications of Oxamyl.

    Journal of nematology·2009
    Same author

    Pathology and histopathology of Pratylenchus scribneri infecting snap bean and lima bean.

    Journal of nematology·2009
    Same author

    Technique for Screening Cowpea Germplasm for Resistance to Root-knot Nematodes.

    Journal of nematology·2009
    Same journal

    Geographical Pattern of Testicular Cancer Points to Maternal Exposures Behind Increasing Incidence.

    International journal of cancer·2026
    Same journal

    High Endothelial Venules in Small Cell Lung Cancer: Prognostic Subtypes and Therapeutic Implications for Immunoradiotherapy.

    International journal of cancer·2026
    Same journal

    Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1-5 and Therapeutic Implications in Neuroendocrine and Non-Neuroendocrine Malignancies.

    International journal of cancer·2026
    Same journal

    Sex Hormone Receptors, HBV Integrations and Their Prognostic Predictive Value Among Hepatocellular Carcinoma Patients.

    International journal of cancer·2026
    Same journal

    MET Expression in Upper Gastrointestinal Adenocarcinoma: Prevalence, Prognostic Impact, and Implications for Anti-MET Antibody-Drug Conjugate Therapy.

    International journal of cancer·2026
    Same journal

    Leveraging Minimal Variables for Maximal Screening Yield: A Global Equity Perspective on Colorectal Cancer Risk Stratification.

    International journal of cancer·2026
    See all related articles

    Area of Science:

    • Neuro-oncology
    • Immunology
    • Biochemistry

    Background:

    • Patients with central nervous system tumors exhibit antibodies against brain tumor cells.
    • Meningioma-associated antigens (MSA) are present in human meningiomas.

    Purpose of the Study:

    • To identify and characterize tumor-associated antigens in brain neoplasms.
    • To detect precipitating antibodies in patient sera against meningioma-associated antigens.

    Main Methods:

    • Extraction and purification of soluble antigens from human meningioma specimens.
    • Serological assays, including immunodiffusion (ID), to detect antibodies in patient sera.
    • Cross-reaction and absorption studies to differentiate antigens and antibodies.

    Main Results:

    Related Experiment Videos

    • 63% of meningioma patients and 53% of glioma patients showed antibodies against two of three meningioma-associated antigens.
    • Antibodies were detected in 17% of patients with other brain neoplasms.
    • Sera from normal donors and non-neural tumor patients showed limited reactivity with one antigen.

    Conclusions:

    • The study identified three distinct meningioma-associated antigens.
    • These antigens can be used to detect specific antibodies in patients with brain tumors, particularly meningiomas and gliomas.
    • The identified antigens are not related to HLA or common human viruses.