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Related Experiment Videos

[Changes in renal function immediately after the angiography]

R Murakami1, H Tajima, T Kumazaki

  • 1Department of Radiology, Nippon Medical School.

Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica
|June 25, 1994
PubMed
Summary
This summary is machine-generated.

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Low osmolar radiographic contrast media, like Iohexol and Iomeprol, temporarily increase urine output and affect kidney function during angiography. These changes, including increased creatinine clearance, are reversible.

Area of Science:

  • Nephrology
  • Radiology
  • Pharmacology

Context:

  • Radiographic contrast media are essential for diagnostic imaging.
  • Assessing the impact of different contrast agents on renal function is crucial for patient safety.
  • Previous studies have shown varied effects of contrast media on kidney function.

Purpose:

  • To investigate the acute effects of three low osmolar contrast media (Ioxaglate, Iohexol, Iomeprol) on renal function in patients with normal kidney function.
  • To compare the renal functional changes induced by different osmolarities and iodine concentrations of contrast agents.

Summary:

  • Thirty patients with normal renal function underwent abdominal angiography using Ioxaglate 320, Iohexol 350, or Iomeprol 400.
  • Parameters including serum/urinary BUN, creatinine, sodium, osmolality, and urinary volume were measured before and after angiography.

Related Experiment Videos

  • All contrast media increased urinary minute volume and fractional excretion of sodium (FENa). Iohexol and Iomeprol also increased creatinine clearance (Ccr), while Ioxaglate did not.

    • Impact:

    • Low osmolar contrast media induce osmotic diuresis and transiently affect proximal tubular function.
    • The observed renal functional changes, including increased Ccr and FENa, are reversible.
    • Findings suggest that Iohexol and Iomeprol may have a more favorable acute renal effect compared to Ioxaglate in this patient cohort.