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Related Experiment Videos

Lactobacillus sp. isolates from mouse livers: saprophyte or potential pathogen?

C J Green, J R Needham, J E Cooper

    Laboratory Animals
    |April 1, 1975
    PubMed
    Summary

    Lactobacillus species were found in mouse livers over three years, with no evidence of mouse hepatitis virus infection. Histopathology showed minimal liver changes, suggesting a lack of significant disease in the studied mouse populations.

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    Area of Science:

    • Microbiology
    • Immunology
    • Veterinary Pathology

    Background:

    • Lactobacillus species are common commensal bacteria.
    • Mouse hepatitis virus (MHV) is an important pathogen in laboratory mice.
    • Understanding the health status of mouse colonies is crucial for research.

    Purpose of the Study:

    • To investigate the presence of Lactobacillus sp. in mouse livers.
    • To assess the serological status for mouse hepatitis virus in the same mice.
    • To perform histopathological examination of liver tissues.

    Main Methods:

    • Isolation of Lactobacillus sp. from liver samples over a 3-year period.
    • Serological testing for mouse hepatitis virus antibodies.
    • Histopathological analysis of liver tissues.

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    Main Results:

    • Lactobacillus sp. was successfully isolated from the livers of both barrier-maintained and conventional mice.
    • No mouse hepatitis virus antibodies were detected in any of the tested mice.
    • Histopathological findings included mild fatty changes and minor monocytic infiltrates.

    Conclusions:

    • The study successfully isolated Lactobacillus sp. from mouse livers.
    • The absence of MHV antibodies indicates no significant MHV infection in the studied colonies.
    • Minimal histopathological changes suggest good liver health in the mice despite Lactobacillus presence.