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Lactobacillus sp. isolates from mouse livers: saprophyte or potential pathogen?
Laboratory Animals
|April 1, 1975
Abstract:
Over a 3-year sampling period Lactobacillus sp. has been isolated from the livers of barrier-maintained and conventional mice. Serology has failed to detect presence of mouse hepatitis virus antibodies in any of these mice. Histopathological examination revealed only mild fatty change and small monocytic infiltrates.
Insights
Lactobacillus species were found in mouse livers over three years, with no evidence of mouse hepatitis virus infection. Histopathology showed minimal liver changes, suggesting a lack of significant disease in the studied mouse populations.
Area of Science:
- Microbiology
- Immunology
- Veterinary Pathology
Background:
- Lactobacillus species are common commensal bacteria.
- Mouse hepatitis virus (MHV) is an important pathogen in laboratory mice.
- Understanding the health status of mouse colonies is crucial for research.
Purpose of the Study:
- To investigate the presence of Lactobacillus sp. in mouse livers.
- To assess the serological status for mouse hepatitis virus in the same mice.
- To perform histopathological examination of liver tissues.
Main Methods:
- Isolation of Lactobacillus sp. from liver samples over a 3-year period.
- Serological testing for mouse hepatitis virus antibodies.
- Histopathological analysis of liver tissues.
Main Results:
- Lactobacillus sp. was successfully isolated from the livers of both barrier-maintained and conventional mice.
- No mouse hepatitis virus antibodies were detected in any of the tested mice.
- Histopathological findings included mild fatty changes and minor monocytic infiltrates.
Conclusions:
- The study successfully isolated Lactobacillus sp. from mouse livers.
- The absence of MHV antibodies indicates no significant MHV infection in the studied colonies.
- Minimal histopathological changes suggest good liver health in the mice despite Lactobacillus presence.