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Nonspecific nasal reactivity and smoking
Annals of Allergy
|August 1, 1994
Summary
This study found that smoking does not increase nasal reactivity to histamine challenges in patients with or without rhinitis or atopy. Nasal histamine sensitivity was similar in both smokers and nonsmokers.
Area of Science:
- Otolaryngology
- Allergy and Immunology
- Pulmonology
Background:
- Nasal hyperreactivity is a key feature in various sinonasal conditions.
- The impact of smoking on non-specific nasal reactivity remains unclear.
Purpose of the Study:
- To investigate whether cigarette smoking alters non-specific nasal reactivity.
- To compare histamine sensitivity in smokers and nonsmokers with and without symptomatic rhinitis or atopy.
Main Methods:
- Intranasal histamine challenge was administered to 23 smokers and 24 nonsmokers.
- Nasal airflow changes were assessed using anterior rhinomanometry to determine histamine sensitivity thresholds.
Main Results:
- The median histamine threshold was 0.4 mg for both smokers and nonsmokers.
- No significant difference in histamine sensitivity was observed between the groups.
- Subgroup analyses were limited by small sample sizes.
Conclusions:
- Cigarette smoke exposure did not appear to increase non-specific nasal reactivity in this study.
- Further research with larger cohorts may be needed to confirm these findings.