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Rifampicin in pneumococcal meningoencephalitis
M J Peters1, B L Pizer, M Millar
1Bristol Royal Hospital for Sick Children.
Archives of Disease in Childhood
|July 1, 1994
Abstract:
The cases are reported of two infants with pneumococcal meningitis in whom initial antibiotic treatment was ineffective despite the organisms being sensitive to the drugs used. A clinical and radiological diagnosis of meningoencephalitis was made. A rapid improvement followed the addition of rifampicin treatment.
Insights
Two infants with pneumococcal meningitis showed no improvement with initial antibiotics. Adding rifampicin led to rapid recovery, suggesting its value in resistant cases.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neurology
Background:
- Pneumococcal meningitis can be challenging to treat, even with sensitive bacteria.
- Meningoencephalitis presents complex clinical and radiological findings.