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Related Experiment Videos

Olfactory memory in unmedicated schizophrenics

J Wu1, M S Buchsbaum, K Moy

  • 1Department of Psychiatry, University of California, Irvine.

Schizophrenia Research
|March 1, 1993
PubMed
Summary
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Schizophrenic patients exhibit olfactory deficits, even before medication. This study confirms smell identification and memory impairments in never-medicated individuals, suggesting limbic system dysfunction.

Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Previous research suggests olfactory deficits in schizophrenic patients.
  • The impact of medication on these deficits remains unclear.

Purpose of the Study:

  • To investigate olfactory function in never-medicated schizophrenic patients.
  • To determine if olfactory deficits are independent of medication effects.

Main Methods:

  • Compared 20 unmedicated schizophrenic patients with 24 healthy controls.
  • Utilized the University of Pennsylvania Smell Identification Test (UPSIT) and a match-to-sample olfactory memory test.

Main Results:

  • Unmedicated schizophrenics performed significantly worse on both smell identification (UPSIT) and olfactory memory tests.

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  • Olfactory memory deficits persisted even after accounting for smell identification abilities.

    • Conclusions:

    • Olfactory identification and memory impairments are present in schizophrenia, independent of medication.
    • These findings support the hypothesis of limbic system dysfunction in schizophrenia.