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Naphtyl methyl imidazoline (NMI) membranes interactions: NMR study and evaluation of possible radioprotective
J C Debouzy1, Y Chancerelle, F Fauvelle
1CRSSA 24, La Tronche, France.
Bollettino Chimico Farmaceutico
|April 1, 1994
Abstract:
The interactions of the radioprotective molecule Naphtyl methyl imidazoline (NMI) with membranes have been studied using biophysical and biochemical methods. 1H, 2H and 31P-NMR methods showed a strong interaction with the deep part of the layer of model membranes inducing the formation of a new membrane compartment. These properties are not involved in the radioprotection effect of NMI which is more probably due to its vasoconstrictive properties.