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Tissue specific perfusion imaging using arterial spin labeling

J A Detre1, W Zhang, D A Roberts

  • 1Department of Neurology, University of Pennsylvania Medical Center, Philadelphia.

NMR in Biomedicine
|March 1, 1994
PubMed
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This study presents a non-invasive magnetic resonance imaging (MRI) method for quantifying tissue perfusion using labeled arterial water. The technique allows for precise measurement of blood flow in various organs, aiding in physiological evaluation.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Physiology

Background:

  • Accurate measurement of regional tissue perfusion is crucial for understanding organ physiology and diagnosing diseases.
  • Existing methods for perfusion quantification often involve invasive procedures or lack sufficient resolution.
  • Magnetic resonance (MR) techniques offer potential for non-invasive physiological measurements.

Purpose of the Study:

  • To develop and validate a quantitative magnetic resonance imaging (MRI) method for measuring regional tissue perfusion.
  • To utilize magnetically labeled arterial water as a diffusable tracer for non-invasive blood flow quantification.
  • To assess the applicability of the technique in various organs and species.

Main Methods:

  • Employs continuous labeling of arterial spins using adiabatic inversion to create a steady-state change in tissue magnetization.

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  • Utilizes standard imaging sequences to sample the altered tissue magnetization, which is tissue-specific.
  • Reviews the theoretical basis, including macromolecular spin saturation, and presents in vitro and in vivo results.

    • Main Results:

    • Demonstrated successful implementation of the technique in vitro and in vivo across rat (brain, heart, kidney) and human (brain, kidney) models.
    • Achieved quantitative perfusion measurements in units of blood flow per gram of tissue per unit time.
    • Showcased the use of a separate RF coil for selective arterial labeling, enabling targeted perfusion imaging in rat brain.

    Conclusions:

    • The developed MR method allows for completely non-invasive, quantitative perfusion imaging at 1H MRI resolution.
    • This technique is valuable for both clinical and investigational assessments of organ physiology.
    • The approach provides a robust tool for evaluating blood flow dynamics in health and disease.