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Permeability pathways for non-electrolytes through Bufo bufo gall-bladder

S Curci, V Casavola, C Lippe

Pflugers Archiv : European Journal of Physiology

|March 26, 1975

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Amphotericin B alters cell membrane permeability, increasing flux for some molecules like D-xylose while decreasing it for others. This polyene effect is influenced by cellular swelling and compound permeability.

Area of Science:

Biochemistry
Cell Biology
Pharmacology

Background:

Amphotericin B is an antifungal polyene antibiotic.
Its mechanism involves altering cell membrane permeability.

Purpose of the Study:

To investigate the effect of Amphotericin B on the transport of various molecules across cell membranes.
To understand how Amphotericin B-induced changes in permeability influence solute flux.

Main Methods:

Flux measurements of thiourea, D-xylose, mannitol, urea, N-methyl-urea, acetamide, formamide, and N-N'-dimethyl-thiourea.
Analysis of the relationship between flux changes and cellular permeability.

Main Results:

Amphotericin B increased fluxes of thiourea, D-xylose, and mannitol.

Related Experiment Videos

It decreased fluxes of urea, N-methyl-urea, acetamide, formamide, and N-N'-dimethyl-thiourea.

Flux inhibition correlated with compound permeability, suggesting increased luminal membrane permeability but reduced lateral membrane diffusion due to cell swelling.

Conclusions:

Amphotericin B increases luminal plasma membrane permeability to various solutes.
Cellular swelling induced by Amphotericin B can mask its permeability-enhancing effects, particularly for lipid-soluble molecules and amides.
The net effect on solute flux depends on the interplay between increased luminal permeability and reduced lateral diffusion.