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Structural and functional changes in salivary glands during aging

S K Kim1, E D Allen

  • 1Research Service, Veterans Administration Medical Center, Ann Arbor, Michigan 48105.

Microscopy Research and Technique
|June 15, 1994
PubMed
Summary
This summary is machine-generated.

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Aging salivary glands show structural changes but retain function. Despite reduced acini, remaining salivary acinar cells maintain protein synthesis and salivary output efficiency in aged animals.

Area of Science:

  • Gerontology
  • Cell Biology
  • Anatomy

Background:

  • Aging significantly impacts salivary gland structure and function.
  • Previous studies noted structural changes like reduced acini and increased ducts in senescent salivary glands.
  • The functional consequences of these structural alterations remain unclear.

Purpose of the Study:

  • To investigate the functional capacity of salivary glands during aging.
  • To determine if structural changes in senescent salivary glands affect salivary output and protein synthesis.
  • To assess the functional efficiency of remaining salivary acinar cells in aged individuals.

Main Methods:

  • Examination of structural and functional changes in salivary glands of senescent and young animals.
  • Analysis of salivary output and composition in aged versus young subjects.

Related Experiment Videos

  • Measurement of protein and messenger RNA (mRNA) synthesis rates in salivary acinar cells.
  • Assessment of acinar cell response to external stimuli for protein synthesis.

    • Main Results:

    • Aging leads to structural changes, including reduced acinar volume and increased ductal volume.
    • Despite structural alterations, salivary output and content remain largely unchanged with age.
    • A decline in protein and mRNA synthesis rates is observed in aged salivary glands.
    • Structurally intact acinar cells from aged animals can effectively synthesize proteins when stimulated.

    Conclusions:

    • Salivary acinar cells retain functional efficiency during aging, even if reduced in number.
    • The remaining acinar cells are sufficient to maintain essential salivary gland functions.
    • Aging-related structural changes do not significantly impair overall salivary gland function.