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Related Experiment Videos

Pleural effusion associated with chronic dantrolene administration

J M Mahoney1, M D Bachtel

  • 1Saint Louis College of Pharmacy.

The Annals of Pharmacotherapy
|May 1, 1994
PubMed
Summary

Chronic dantrolene use can lead to pleural effusion, a rare side effect. Discontinuing dantrolene therapy typically resolves this condition over several months.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Internal Medicine

Background:

  • Dantrolene is a muscle relaxant used for chronic spasticity.
  • Pleural effusion is a rare but serious adverse effect associated with dantrolene therapy.

Observation:

  • A 35-year-old male developed pleural effusion with eosinophilia after 12 years of low-dose dantrolene therapy.
  • Symptoms resolved gradually over several months after dantrolene discontinuation.

Findings:

  • Pleural effusion associated with chronic dantrolene administration.
  • Pleural and peripheral eosinophilia were noted in the case.
  • Dantrolene withdrawal led to symptom resolution.

Implications:

  • Clinicians should consider dantrolene-induced disease in patients on chronic therapy presenting with pleural effusions.
  • Discontinuation of dantrolene is generally effective in managing this adverse reaction.

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