Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute lymphoblastic leukaemia in the elderly

P R Taylor1, M M Reid, S J Proctor

  • 1Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Leukemia & Lymphoma
|May 1, 1994
PubMed
Summary

Acute lymphoblastic leukemia (ALL) is rare in older adults, presenting unique cytogenetic and immunophenotypic patterns. Treatment outcomes are poor, with limited remission rates and survival, indicating a challenging stem cell disorder in this population.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A precise measurement of the [Formula: see text] meson oscillation frequency.

The European physical journal. C, Particles and fields·2017
Same author

Search for long-lived heavy charged particles using a ring imaging Cherenkov technique at LHCb.

The European physical journal. C, Particles and fields·2015
Same author

Evidence for the Strangeness-Changing Weak Decay Ξ_{b}^{-}→Λ_{b}^{0}π^{-}.

Physical review letters·2015
Same author

Search for Hidden-Sector Bosons in B(0)→K(*0)μ(+)μ(-) Decays.

Physical review letters·2015
Same author

Measurement of the ratio of branching fractions B(B[over ¯]^{0}→D^{*+}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]^{0}→D^{*+}μ^{-}ν[over ¯]_{μ}).

Physical review letters·2015
Same author

First observation of top quark production in the forward region.

Physical review letters·2015

Area of Science:

  • Hematology
  • Oncology
  • Geriatrics

Background:

  • Acute lymphoblastic leukemia (ALL) is uncommon in adults over 60.
  • Incidence is approximately 1 per 100,000 annually.
  • Distinct characteristics differentiate elderly ALL from younger patients.

Purpose of the Study:

  • To review current literature on elderly ALL.
  • To analyze regional experience with 62 consecutive cases in this age group.
  • To compare patterns with younger adults and childhood ALL.

Main Methods:

  • Literature review of sparse data.
  • Analysis of 62 consecutive cases of elderly ALL over ten years.
  • Comparison of cytogenetic and immunophenotypic profiles.

Main Results:

  • B-ALL was twice as common (9/51) compared to younger adults (6/99).
  • T-ALL was rare (2/51).
  • Literature suggests up to 50% Philadelphia positivity, indicating a stem cell disorder.

Conclusions:

  • Elderly ALL is rare with a very poor prognosis.
  • Complete remission rates were only 30% with aggressive treatment.
  • Overall four-year survival was 4%, with a 92% relapse rate.

Related Experiment Videos