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Intradermal rabies immunization for pre- and post-exposure prophylaxis
J K Dutta1, M J Warrell, T K Dutta
1Centre for Tropical Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
The National Medical Journal of India
|May 1, 1994
Summary
Intradermal injections of human diploid cell rabies vaccine are a cost-effective alternative to traditional treatments in India. This method significantly reduces the expense of post-exposure rabies treatment, making it more accessible.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Background:
- Human diploid cell rabies vaccine (HDCV) and other tissue culture vaccines are currently too expensive for widespread use in India.
- Nervous tissue vaccines, while cheaper, are associated with higher risks.
Purpose of the Study:
- To evaluate the efficacy, economy, and safety of alternative vaccination regimens for rabies post-exposure treatment in India.
- To determine if multiple-site intradermal injections of tissue culture vaccines can reduce treatment costs.
Main Methods:
- Utilizing multiple-site intradermal injections of tissue culture rabies vaccine.
- Comparing the cost-effectiveness of this method against existing post-exposure treatment protocols.
Main Results:
- The intradermal injection method proved to be effective, economical, and safe.
- This alternative regimen can reduce the cost of post-exposure rabies treatment by up to 60%.
Conclusions:
- Multiple-site intradermal injections of tissue culture rabies vaccine offer a viable and affordable alternative for rabies prevention in India.
- This approach can accelerate the transition from older, riskier nervous tissue vaccines to modern, safer tissue culture vaccines.