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Intradermal rabies immunization for pre- and post-exposure prophylaxis

J K Dutta¹, M J Warrell, T K Dutta

¹Centre for Tropical Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

The National Medical Journal of India

|May 1, 1994

Summary

Intradermal injections of human diploid cell rabies vaccine are a cost-effective alternative to traditional treatments in India. This method significantly reduces the expense of post-exposure rabies treatment, making it more accessible.

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Area of Science:

Immunology
Vaccinology
Public Health

Background:

Human diploid cell rabies vaccine (HDCV) and other tissue culture vaccines are currently too expensive for widespread use in India.
Nervous tissue vaccines, while cheaper, are associated with higher risks.

Purpose of the Study:

To evaluate the efficacy, economy, and safety of alternative vaccination regimens for rabies post-exposure treatment in India.
To determine if multiple-site intradermal injections of tissue culture vaccines can reduce treatment costs.

Main Methods:

Utilizing multiple-site intradermal injections of tissue culture rabies vaccine.
Comparing the cost-effectiveness of this method against existing post-exposure treatment protocols.

Main Results:

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The intradermal injection method proved to be effective, economical, and safe.
This alternative regimen can reduce the cost of post-exposure rabies treatment by up to 60%.

Conclusions:

Multiple-site intradermal injections of tissue culture rabies vaccine offer a viable and affordable alternative for rabies prevention in India.
This approach can accelerate the transition from older, riskier nervous tissue vaccines to modern, safer tissue culture vaccines.