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[Veratrum alkaloids. I]

D Grancai1, Z Grancaiová

  • 1Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava.

Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti
|July 1, 1994
PubMed
Summary

This study surveys Veratrum alkaloids, potent compounds found in plants like Veratrum, Schoenocaulon, and Zygadenus. It details the classification and characteristics of jervanine, veratranine, and cevanine-type alkaloids.

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Medicinal Chemistry

Context:

  • Alkaloids are vital secondary metabolites with significant therapeutic applications.
  • Plants from the Veratrum genus, along with Schoenocaulon and Zygadenus, are known sources of antihypertensive veratrum alkaloids.

Purpose:

  • To present a comprehensive survey of alkaloids isolated from 17 Veratrum species.
  • To classify these Veratrum alkaloids according to IUPAC steroid nomenclature into seven groups.
  • To detail the first two groups: jervanine and veratranine types (I-XXIII) and cevanine skeleton alkaloids (XXIV-XXXV).

Summary:

  • The study surveys alkaloids from the underground and aerial parts of 17 Veratrum species.
  • Alkaloids were found as glycosides, aglycones, or esters.
  • Compounds were classified into jervanine, veratranine, and cevanine types, with their physico-chemical properties detailed.

Impact:

  • Provides a systematic classification of Veratrum alkaloids based on IUPAC nomenclature.
  • Characterizes specific alkaloid types, including jervanine, veratranine, and cevanine skeletons.
  • Contributes to the understanding of plant-derived compounds with potential pharmaceutical value, particularly for hypertension treatment.

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