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Efficient entrapment of amikacin and teicoplanin in liposomes
M Ravaoarinoro1, E Toma, O Agbaba
1Hôtel-Dieu de Montréal, Qué., Canada.
Journal of Drug Targeting
|January 1, 1993
Abstract:
A higher encapsulation rate was obtained using the dehydration-rehydration method compared with the reverse-phase evaporation technique in negative multilamellar vesicles with amikacin (AMK) (45% versus 15%; P < 0.05) and teicoplanin (TCP) (34% versus 25%; P < 0.05). The addition of 250 mM sucrose to AMK- or TCP-containing liposomes without prior drying prevented a significant decrease in antibiotic content in unilamellar and multilamellar vesicles over a 3-month period at -70 degrees C.