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Cd2+ and Co2+ at micromolar concentrations stimulate catecholamine secretion by increasing the cytosolic free Ca2+
K Yamagami1, S Nishimura, M Sorimachi
1Department of Physiology, Kagoshima University, School of Medicine, Japan.
Brain Research
|May 23, 1994
Abstract:
Cd2+ and Co2+ at micromolar concentrations increased the cytosolic free Ca2+ concentration, which was measured by fura-2 microfluorometry, in cat adrenal chromaffin cells. Simultaneously, these divalent cations stimulated catecholamine secretion from the perfused adrenal. The present findings suggest that these cations increase the Ca2+ influx by depolarizing the cell membrane and consequently stimulate catecholamine secretion.