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Related Experiment Videos

Gastric fibrinolysis

I M Nilsson, S E Bergentz, U Hedner

    Thrombosis Et Diathesis Haemorrhagica
    |November 15, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Erosive haemorrhagic gastroduodenitis involves local gastric fibrinolysis, leading to bleeding. This study identified plasmin in gastric juice, suggesting a mechanism for bleeding tendency in these patients.

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    Area of Science:

    • Gastroenterology
    • Hematology
    • Biochemistry

    Background:

    • Gastric ulcer and erosive haemorrhagic gastroduodenitis are common gastrointestinal conditions.
    • Fibrinolysis, the breakdown of fibrin, plays a role in hemostasis and pathological bleeding.
    • The role of local gastric fibrinolysis in the pathogenesis of bleeding in these conditions is not fully understood.

    Purpose of the Study:

    • To investigate the fibrinolytic activity and plasmin content in gastric juice of patients with gastric ulcer and erosive haemorrhagic gastroduodenitis.
    • To compare these findings with normal individuals.
    • To explore the potential contribution of local gastric fibrinolysis to bleeding tendency.

    Main Methods:

    • Analysis of gastric juice from normal individuals, gastric ulcer patients, and erosive haemorrhagic gastroduodenitis patients.

    Related Experiment Videos

  • Assay of fibrinolytic activity using unheated and heated human fibrin plates.
  • Immunochemical detection of fibrin degradation products (FDP), plasminogen, and plasmin.
  • In vitro and in vivo inhibition studies using EACA and AMCA.

    • Main Results:

    • Normal gastric juice showed no fibrinolytic activity or detectable FDP/plasminogen.
    • Gastric ulcer patients exhibited minimal or no fibrinolytic activity, attributed to non-specific proteolytic activity (trypsin).
    • Erosive haemorrhagic gastroduodenitis patients displayed significantly high gastric juice fibrinolytic activity, higher on unheated than heated plates, with demonstrable plasmin and plasminogen activator. This activity was inhibited by EACA and AMCA.
    • Blood analysis in erosive haemorrhagic gastroduodenitis patients revealed low plasminogen and alpha2-M, and FDP in serum, indicating local gastric fibrinolysis.

    Conclusions:

    • Erosive haemorrhagic gastroduodenitis is characterized by local fibrinolysis in the stomach and duodenum.
    • The presence of plasminogen activator and plasmin in gastric juice contributes to the bleeding tendency in these patients.
    • Administration of AMCA demonstrated a therapeutic effect on fibrinolytic activity and hemorrhage, supporting the role of gastric fibrinolysis in bleeding.