Polysialic acid expression in the salamander retina is inducible by thyroxine
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C G Becker1, T Becker, A Schmidt
1Brain Research Institute, University of Bremen, Germany.
Brain Research. Developmental Brain Research
|May 13, 1994
Abstract:
Polysialylation of the neural cell adhesion molecule (NCAM) in the retina of Pleurodeles waltl is up-regulated during metamorphosis. Incubation of larvae in thyroxine permanently induced polysialic acid expression in the retina in a concentration-dependent but age-independent manner within 3 days of incubation (3 x 10(-7) M). Retinoic acid had no effect. This suggests direct hormonal regulation of a post-translational modification of NCAM in the amphibian retina.