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[A study on the resistance of methicillin resistant Staphylococcus aureus to antimicrobial agents]
1Research Unit of Clinical Pharmacology, Chinese PLA General Hospital.
Abstract:
The morbidity of the infections caused by methicillin resistant staphylococcus aureus increased in recent years. In order to know the resistance of MRSA to antimicrobial agents, the minimal inhibitory concentrations (MICs) of antimicrobial agents against S. Aureus isolated from inpatients were measured. The presence of beta-lactamase in and the types of coagulase of the strains tested were determined as well. The results showed that MRSA accounted for 50.7% of the strains tested, the incidence of MRSA producing beta-lactamase was 85.1% and the coagulase of MRSA was all of type II. MRSA showed resistance to most of the lactam antibiotics and some of the aminoglycosides. Vancomycin and arbikacin had the highest activity against MRSA; other effective antibiotics were in the following order: amikacin, minocycline, tosulfloxacin and imipenem. It is suggested that serious infections caused by MRSA may be cured by using vancomycin, arbikacin or other antibiotics mentioned above.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) infections are rising. This study found MRSA strains highly resistant to common antibiotics but susceptible to vancomycin and arbikacin, offering treatment options.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Increasing morbidity associated with methicillin-resistant Staphylococcus aureus (MRSA) infections.
- Need to understand antimicrobial resistance patterns of MRSA strains.
- Importance of identifying effective treatment strategies against MRSA.
Purpose of the Study:
- To determine the antimicrobial resistance profiles of Staphylococcus aureus strains isolated from inpatients.
- To assess the prevalence of beta-lactamase production and coagulase types in MRSA strains.
- To identify effective antimicrobial agents against MRSA.
Main Methods:
- Measurement of minimal inhibitory concentrations (MICs) for various antimicrobial agents against isolated S. Aureus strains.
- Determination of beta-lactamase presence in the strains.
- Classification of coagulase types for the tested MRSA strains.
Main Results:
- MRSA constituted 50.7% of the isolated strains.
- 85.1% of MRSA strains produced beta-lactamase; all were coagulase type II.
- MRSA exhibited resistance to most lactam antibiotics and some aminoglycosides. Vancomycin and arbikacin showed the highest activity, followed by amikacin, minocycline, tosulfloxacin, and imipenem.
Conclusions:
- MRSA strains isolated from inpatients display significant resistance to common antibiotics.
- Vancomycin and arbikacin are highly effective against these MRSA strains.
- The study suggests vancomycin, arbikacin, and other identified effective antibiotics for treating serious MRSA infections.