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Serum lipids and thyrotropin in women with coronary artery disease

P J Stubbs1, B D Mulrooney, P O Collinson

  • 1Academic Unit of Cardiovascular Medicine, Charing Cross and Westminster Medical School, U.K.

European Heart Journal
|April 1, 1994
PubMed

Insights

Even within the normal range, thyroid-stimulating hormone (TSH) significantly impacts lipid levels in women with ischaemic heart disease (IHD). This suggests a subtle thyroid-lipid connection in IHD patients.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Clinical Biochemistry

Background:

  • Thyroid dysfunction is linked to altered lipid profiles and increased ischaemic heart disease (IHD) risk.
  • The relationship between normal thyroid function, lipid concentrations, and IHD remains unclear.

Purpose of the Study:

  • To investigate the association between thyroid function, serum lipids, and IHD in euthyroid women.
  • To determine if subclinical thyroid function variations influence lipid levels in the context of IHD.

Main Methods:

  • Studied 46 euthyroid women, including 23 with IHD and 23 matched controls.
  • Excluded patients with conditions or medications affecting lipid or thyroid metabolism.
  • Analyzed correlations between thyrotropin (TSH) and lipid profiles (cholesterol, LDL, triglycerides).

Main Results:

  • Found significant correlations between TSH and cholesterol, LDL, and triglycerides in the IHD group, but not in controls.
  • Analysis of covariance revealed significant differences in the association between TSH and lipids between the IHD and control groups.
  • TSH within the normal range demonstrated a statistically significant effect on lipid levels in women with IHD.

Conclusions:

  • Thyroid-stimulating hormone (TSH) within the normal physiological range exerts a significant influence on serum lipid concentrations in women with ischaemic heart disease.
  • These findings highlight a potential mechanism linking subtle thyroid function variations to cardiovascular risk in euthyroid individuals.
  • Further research may elucidate the clinical implications of these TSH-lipid associations in managing IHD.

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