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[Tamoxifen and spermatogenesis in rats subjected to effects of estradiol]
K Kula1, I M Salata, J Słowikowska-Hilczer
1Pracowni Andrologii Klinicznej Instytutu Endokrynologii AM, Lodzi.
Abstract:
During 14 subsequent days male Wistar rats received subcutaneously 50 micrograms of EB and different doses of tamoxifen intratesticularly. Action of EB was examined by comparison with the group, which received the solvent for EB only. EB caused the reduction in the mean testis weight, degenerative changes of germinal cells and decrease of blood testosterone level to undetectable values. Tamoxifen did not prevent these changes, but revealed a positive influence on the mean numbers of spermatogonia, spermatocytes and spermatids, including spermatozoa. It indicates that tamoxifen may stimulate the whole spermatogenesis in spite of the inhibition of testosterone production.