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Coagulase expression in Staphylococcus aureus is positively and negatively modulated by an agr-dependent mechanism
C Lebeau1, F Vandenesch, T Greenland
1Département de Recherche en Bactériologie Médicale EA 1655, Faculté de Médecine Alexis Carrel, Lyon, France.
Journal of Bacteriology
|September 1, 1994
Abstract:
Expression of staphylocoagulase by agr+ Staphylococcus aureus depends on the growth phase, being maximal during exponential growth and decreasing sharply postexponentially, while an agr-deleted strain continuously expresses an intermediate level of coagulase. Therefore, coagulase expression appears to be both positively and negatively modulated by an agr-dependent mechanism.