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Hypozincemia in depression

M Maes1, P C D'Haese, S Scharpé

  • 1Department of Psychiatry, Case Western Reserve University, Cleveland, OH.

Journal of Affective Disorders
|June 1, 1994
PubMed
Summary
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This study found lower serum zinc levels in major depression, correlating with illness severity and immune markers. These findings suggest a link between low zinc and immune system activation in depression.

Area of Science:

  • Biochemistry
  • Immunology
  • Psychiatry

Background:

  • Depression is a complex mood disorder with various biological underpinnings.
  • Previous research has suggested potential roles for trace elements and immune system dysregulation in depression.

Purpose of the Study:

  • To investigate serum zinc levels in different subtypes of unipolar depression.
  • To explore the relationship between serum zinc, immune markers (neopterin), and hormonal responses in depression.

Main Methods:

  • Serum zinc levels were measured in 48 unipolar depressed subjects and 32 healthy controls.
  • Correlations were analyzed between zinc levels, depression severity, plasma neopterin, and postdexamethasone hormone levels.

Main Results:

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  • Major depressed subjects exhibited significantly lower serum zinc compared to normal controls.
  • Serum zinc levels showed a negative correlation with depression severity and plasma neopterin concentrations.
  • No significant association was found between serum zinc and postdexamethasone hormone levels or anorexia/weight loss.

Conclusions:

  • Hypozincemia (low serum zinc) may be a feature of major depression.
  • The findings suggest a potential link between low zinc levels and activated cell-mediated immunity in major depression.