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Sertraline in social phobia

M Van Ameringen¹, C Mancini, D Streiner

¹Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada.

Journal of Affective Disorders

|June 1, 1994

Summary

Sertraline treatment significantly improved social anxiety, depression, and social functioning in patients with Social Phobia. The study found 80% of participants responded positively to the 12-week open trial.

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Area of Science:

Psychiatry
Clinical Psychology
Pharmacology

Background:

Social Phobia is a prevalent anxiety disorder characterized by significant distress and impairment.
Effective pharmacological treatments are crucial for managing Social Phobia symptoms.

Purpose of the Study:

To evaluate the efficacy and tolerability of sertraline in patients diagnosed with Social Phobia.
To assess the impact of sertraline on social anxiety, avoidance, depressive symptoms, and social functioning.

Main Methods:

An open-label, 12-week trial was conducted with 22 patients diagnosed with Social Phobia according to DSM-III-R criteria.
Participants received sertraline treatment, and outcomes were measured using various scales assessing social anxiety, depression, and social functioning.
Twenty patients completed at least 8 weeks of the treatment protocol.

Main Results:

A significant improvement was observed in all measured outcomes, including social anxiety, avoidance, depression, and social functioning, from baseline to the end of the study.
Sixteen out of 20 completers (80%) were classified as responders, indicating a positive clinical response to sertraline.
Four patients (20%) were classified as non-responders.

Conclusions:

Sertraline demonstrated significant efficacy in treating Social Phobia, leading to substantial improvements in social anxiety, depressive symptoms, and overall social functioning.
The findings support the use of sertraline as a viable treatment option for individuals suffering from Social Phobia.
Further research with controlled trials is warranted to confirm these findings and establish optimal treatment parameters.

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