Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure evolution of tablets during compression unloading

E G Rippie1, W T Morehead

  • 1Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis 55455.

Journal of Pharmaceutical Sciences
|May 1, 1994
PubMed
Summary

During tablet compaction unloading, internal fractures form due to stress release. This study quantifies these changes using viscoelastic analysis, revealing fracture dynamics in pharmaceutical compacts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consolidation mechanisms of pharmaceutical solids: a multi-compression cycle approach.

Pharmaceutical research·1997
Same author

Nondestructive viscoelastic analysis of anisotropy in compressed tablets.

Journal of pharmaceutical sciences·1997
Same author

Determination of intraparticulate mass transfer coefficients via permeation measurements: theory and experimental validation.

Pharmaceutical development and technology·1996
Same author

Thermodynamic analysis of energy dissipation by pharmaceutical tablets during stress unloading.

Journal of pharmaceutical sciences·1994
Same author

Timing relationships among maxima of punch and die-wall stress and punch displacement during compaction of viscoelastic solids.

Journal of pharmaceutical sciences·1990
Same author

Evidence for site-specific absorption of a novel ACE inhibitor.

Pharmaceutical research·1989

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Solid Mechanics

Background:

  • Tablet compaction is crucial in pharmaceutical manufacturing.
  • Understanding the unloading phase is key to tablet integrity.
  • Internal structure evolution impacts tablet performance.

Purpose of the Study:

  • To investigate the internal structural evolution of pharmaceutical compacts during the unloading phase of compaction.
  • To quantitatively measure changes in compact behavior during unloading.
  • To elucidate the mechanisms of fracture generation and propagation.

Main Methods:

  • Utilized an instrumented rotary tablet press for compaction studies.
  • Applied three-dimensional viscoelastic analysis to sequential segments of the unloading phase.

Related Experiment Videos

  • Obtained quantitative elastic and viscous parameters to characterize compact behavior.

    • Main Results:

    • Identified internal fracture generation and propagation as the primary event during unloading.
    • Observed a progression of elastic parameters from positive to negative values.
    • Established strong correlations between elastic and viscous parameters.
    • Demonstrated that fracture dynamics align with Dugdale fracture principles.

    Conclusions:

    • The unloading phase is characterized by stress-induced internal fracturing.
    • Viscoelastic analysis provides quantitative insights into compact behavior during unloading.
    • Fracture propagation is influenced by material properties and crack growth extent.