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Updated: Aug 19, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
[Pharmacologic analysis of the free radical mechanism of poisoning-induced memory disorders]
Abstract:
Ethylene glycol, the pyrethroid pesticide deltametrin, and the m-cholinolytics atropine and scopolamine disturb the formation and storage of signs of memory in rats appraised in the test for conditional reaction of passive and active avoidance. The antioxidants alpha-tocopherol and sodium selenite, the nootropic agent piracetam, and the amino acid L-tryptophan prevent amnesia. Spectrometry of optic density in a "diphenylpicrylhydrazil-drug" model system showed the existence of anti-radical activity in piracetam and L-tryptophan. It is suggested that the anti-amnestic efficacy of piracetam and L-tryptophan is associated, to a certain measure, with their antioxidant properties.
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