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Related Experiment Videos

Effect on pressor and vascular responsiveness in rabbits of drugs that decrease norepinephrine uptake

D G Koivunen1, J A Johnson

  • 1H. S. Truman Memorial Veterans Administration Medical Center, Columbia 65201.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|September 1, 1994
PubMed
Summary

Decreased norepinephrine (NE) uptake enhances blood pressure and vascular responses to vasoconstrictors like NE and arginine vasopressin (AVP). This suggests impaired NE uptake contributes to hyperresponsiveness in conditions like renal prehypertension.

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Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Neuroscience

Background:

  • Norepinephrine (NE) plays a crucial role in regulating blood pressure and vascular tone.
  • Impaired NE reuptuptake is implicated in various hypertensive states.
  • Understanding the mechanisms of vascular hyperresponsiveness is key to managing hypertension.

Purpose of the Study:

  • To investigate whether reduced NE uptake leads to exaggerated pressor and vascular responses.
  • To examine the effects of cocaine and imipramine on pressor and vascular reactivity to NE and AVP.

Main Methods:

  • Conscious rabbits were administered cocaine or imipramine to inhibit NE uptake.
  • Responses in mean arterial pressure and total peripheral resistance (TPR) to infused NE and AVP were measured.

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  • Comparisons were made between drug-treated and control groups.

    • Main Results:

    • Cocaine and imipramine significantly amplified the pressor and TPR responses to both NE and AVP infusions.
    • These effects were observed at all tested doses of NE.
    • Enhanced responses in treated rabbits indicate hyperresponsiveness induced by reduced NE uptake.

    Conclusions:

    • Cocaine and imipramine induce pressor and vascular hyperresponsiveness to NE and AVP in rabbits.
    • These findings support the hypothesis that decreased NE uptake contributes to vascular hyperresponsiveness.
    • Reduced NE uptake by sympathetic nerve terminals may be a factor in renal prehypertension.