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Updated: Sep 12, 2026

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor (IRIS)
Published on: May 3, 2011
Structural considerations on the iridoids as anti-inflammatory agents
M C Recio1, R M Giner, S Máñez
1Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.
Abstract:
Twelve iridoid glycosides have been evaluated for their anti-inflammatory activity on two models: the carrageenan-induced mouse paw edema and the TPA-induced mouse ear edema. Loganic acid was the most active (44.4% edema inhibition) on the former test, whereas the catalpol derivative mixture isolated from Scrophularia, aucubin, verbenalin, and loganin, showed the highest activity (from 72.0 to 80.0% edema inhibition) on the latter. The results allowed us to establish the relationship between the structure and anti-inflammatory activity on the basis of the different patterns of substitution, particularly hydroxylation, unsaturation, and acylation.
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