Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells

The modulated, 160-MeV proton beam produced by the Harvard Cyclotron has been examined in detail for its ability to kill mammalian cells as assayed by colony forming ability. Using two different cell exposure techniques, the characteristics of position and total dose in producing cell death in two aneuploid cell lines selected for their radiobiological relevance have been determined...