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Human imprinted genes as oncodevelopmental markers

H Biran1, I Ariel, N de Groot

  • 1Sheiba Institute of Oncology, Kaplan Hospital, Rehovot, Israel.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|January 1, 1994
PubMed
Summary
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Imprinted genes like human insulin-like growth factor 2 (IGF2) and H19 are vital for development. Their reexpression in pediatric tumors and association with invasiveness suggest they are crucial tumor markers.

Area of Science:

  • Genetics
  • Developmental Biology
  • Oncology

Background:

  • Imprinted genes, such as human insulin-like growth factor 2 (IGF2) and H19, play critical roles in prenatal development, exhibiting unique maternal or paternal expression patterns.
  • These genes are typically downregulated after birth but reemerge in certain pediatric tumors and developmental syndromes linked to cancer.
  • The oncofetal expression pattern of IGF2 and H19 is observed in various cancers, including Wilms' tumor, rhabdomyosarcoma, ovarian teratoma, and gestational trophoblastic diseases.

Purpose of the Study:

  • To investigate the role of imprinted genes, specifically IGF2 and H19, as potential tumor markers.
  • To explore the expression patterns of H19 and IGF2 in different tumor types and their correlation with disease characteristics.

Main Methods:

Related Experiment Videos

  • Analysis of H19 and IGF2 gene expression in placental tissues and urothelial carcinoma.
  • Correlation of H19 expression levels with the degree of tumor invasiveness.

    • Main Results:

    • H19 and IGF2 are expressed during embryonal development and in the placenta.
    • Reexpression of H19 and IGF2 is observed in pediatric tumors like Wilms' tumor.
    • H19 expression in the placenta and urothelial carcinoma correlates with tumor invasiveness.

    Conclusions:

    • The tissue-specific, oncofetal expression pattern of IGF2 and H19 suggests their involvement in tumorigenesis.
    • H19 and IGF2 show potential as diagnostic and prognostic tumor markers due to their altered expression in cancer and correlation with invasiveness.