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[Vitamin D: clinical aspects and therapy]

R Krapf1

  • 1Klinik B für Innere Medizin, Kantonsspital St. Gallen.

Therapeutische Umschau. Revue Therapeutique
|July 1, 1994
PubMed
Summary

This review covers vitamin D3 metabolism and regulation, focusing on kidney enzyme control. Vitamin D3 effectively treats deficiencies and certain bone conditions like osteoporosis and renal osteodystrophy.

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Area of Science:

  • Biochemistry and Endocrinology
  • Nutritional Science

Background:

  • Vitamin D3 is crucial for calcium homeostasis and bone health.
  • Its metabolism involves complex regulation, particularly in the kidneys.
  • Current therapeutic applications are well-documented for specific conditions.

Purpose of the Study:

  • To review the metabolism and regulation of vitamin D3.
  • To emphasize the regulation of renal 25-hydroxy-vitamin D3 1-alpha-hydroxylase.
  • To discuss established and potential therapeutic uses of vitamin D3 and its analogs.

Main Methods:

  • Literature review of vitamin D3 metabolism and regulation.
  • Analysis of therapeutic utility in various clinical entities.
  • Discussion of the role of renal 25-hydroxy-vitamin D3 1-alpha-hydroxylase.

Main Results:

  • Vitamin D3 is therapeutically beneficial for deficiency, involutional osteoporosis, glucocorticoid-induced osteoporosis, and renal osteodystrophy.
  • Established therapeutic benefits are lacking for hematological neoplasias, other neoplasias, and psoriasis.
  • Noncalcemic vitamin D3 analogs show promise for expanded indications.

Conclusions:

  • Vitamin D3 plays a vital role in treating specific bone disorders.
  • Further research into vitamin D3 analogs could broaden therapeutic applications, especially for renal osteodystrophy.

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