Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebral hyperemia in MELAS

T I Gropen1, I Prohovnik, T K Tatemichi

  • 1Department of Neurology, State University of New York, Health Science Center at Brooklyn.

Stroke
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic yield of brain CT in a limited-access environment.

International journal of psychiatry in clinical practice·2014
Same author

Cerebral white matter disruption in Creutzfeldt-Jakob disease.

AJNR. American journal of neuroradiology·2012
Same author

The Creutzfeldt-Jakob disease (CJD) neurological status scale: a new tool for evaluation of disease severity and progression.

Acta neurologica Scandinavica·2011
Same author

Rapidly progressive Creutzfeldt-Jakob disease in patients with Familial Mediterranean Fever.

European journal of neurology·2010
Same author

Enhanced detection of diffusion reductions in Creutzfeldt-Jakob disease at a higher B factor.

AJNR. American journal of neuroradiology·2009
Same author

MR imaging of familial Creutzfeldt-Jakob disease: a blinded and controlled study.

AJNR. American journal of neuroradiology·2008

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) causes cerebral hyperemia and altered CO2 reactivity. Imaging findings in MELAS may be misleading, highlighting the need for careful interpretation.

Area of Science:

  • Neurology
  • Neuroimaging
  • Mitochondrial Diseases

Background:

  • The pathophysiology of stroke-like episodes in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) remains unclear.
  • MELAS is a rare genetic disorder affecting energy production in cells, leading to neurological complications.

Observation:

  • A 24-year-old male with MELAS presented with aphasia and hemianopia following a stroke-like episode.
  • Cerebral imaging revealed extensive infarction in the parietal, temporal, and occipital lobes.
  • Serial cerebral blood flow studies showed generalized hyperemia, initially in infarcted areas and later in noninfarcted tissues.

Findings:

  • Generalized cerebral hyperemia was observed in the MELAS patient, persisting for months after the stroke-like episode.

Related Experiment Videos

  • Carbon dioxide (CO2) reactivity was initially reduced in the infarct but improved over time.
  • Vasomotor reactivity was impaired in noninfarcted regions during peak hyperemia.

    • Implications:

    • The observed hyperemia and fluctuating CO2 reactivity in MELAS may be linked to local lactic acid production.
    • Nonquantitative functional imaging techniques might yield misleading results in MELAS patients.
    • Understanding these hemodynamic changes is crucial for accurate diagnosis and management of MELAS.