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[BCG potentiates the immunodepression induced by cyclophosphamide]

G Mathé, O Halle-Pannenko, C Bourut

    Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences. Serie D: Sciences Naturelles
    |April 14, 1975
    PubMed

    Compared to the effect of CPM alone, the survival of allogeneic C3H skin grafts on Fl (DBA/2 X C57Bl/6) recipients is considerably enhanced when the recipient is given BCG (1 mg/mouse) 14 days before the graft and CPM (80 or 134 mg/kg) one day after the graft. While other mechanisms cannot be entirely excluded, it is possible that BCG stimulates the lymphocytes to enter the cell cycle, which makes them more sensitive to CPM, a cycle-dependent agent.

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