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Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
Published on: December 29, 2015
[The properties of simian coronavirus]
Voprosy Virusologii
|May 1, 1993
Summary
Two simian coronavirus (CV) strains, CVRM 281 and CVP 250, were identified from monkeys. These prototype strains offer potential for diagnostic use and modeling human infections.
Area of Science:
- Virology
- Primatology
Background:
- Coronaviruses (CV) are a significant group of viruses with implications for both animal and human health.
- Investigating simian CVs provides insights into viral diversity and potential zoonotic transmission.
Purpose of the Study:
- To characterize novel simian coronavirus isolates from Papio hamadryas and rhesus monkeys.
- To identify and propose prototype strains for the Coronaviridae family.
- To evaluate the potential of these strains for diagnostic applications and as models for human infections.
Main Methods:
- Isolation and characterization of 20 simian coronavirus (CV) strains from infected non-human primates.
- Comparative analysis of biological properties and polypeptide profiles of selected strains.
- Antigenic grouping and comparison with established mammalian CV prototype strains.
Main Results:
- Two simian CV prototype strains, CVRM 281 (rhesus monkey) and CVP 250 (Papio hamadryas), were selected.
- These strains are closely related but exhibit distinct biological properties and polypeptide compositions.
- Both strains belong to the 2nd antigen group of mammalian CVs, distinct from HCV OC 43.
- Strain CVRM 281 induces experimental CV infection, serving as a potential model for human CV infections.
Conclusions:
- The identified simian CV strains CVRM 281 and CVP 250 are suitable candidates for the Coronaviridae family.
- These viruses demonstrate utility for diagnostic purposes in virology.
- Strain CVRM 281 offers a valuable model for studying aspects of human coronavirus infections.
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